Treatment with Me-RCR (200 and 400 mg/kg, b.w.) notably increased the number of open arm entries and the time spent in the EPM test. Computational investigations were performed using computer-aided methods for screening the anxiolytic, antidepressant, and antioxidative activities of the selected lead molecules. The in-depth antioxidative potential of Me-RCR was also evaluated through DPPH radical scavenging activity, ferric-reducing power capacity, total phenolic, flavonoid, flavonol, and antioxidant content analysis.
#SCORN LACERA SKIN PLUS#
The antidepressant and anxiolytic properties of Me-RCR were assessed by using elevated plus maze (EPM), hole-board (HBT), tail suspension (TST), and forced swimming (FST) tests in Swiss Albino mice. recurvata rhizome (Me-RCR) through different approaches. The present study aimed to evaluate the antidepressant and anxiolytic activities of a methanol extract of C. Palm grass (Curculigo recurvata) is an ethnomedicinally important herb reported to have significant medicinal values. However, many members of the species of the genus Syzygium need further comprehensive studies regarding phytochemical constituents and mechanism‐based pharmacological activities. Bioactive compounds such as flavanone derivatives, ellagic acid derivatives and other polyphenolics, and terpenoids are reported from several species of the genus Syzygium. The information related to genus Syzygium was analytically composed from the scientific databases, including PubMed, Google Scholar, Science Direct, Web of Science, Wiley Online Library, Springer, Research Gate link, published books, and conference proceedings. The aim of this review is to describe the scientific works and to provide organized information on the available traditional uses, phytochemical constituents, and pharmacological activities of mostly available species of the genus Syzygium in Bangladesh. Moreover, plants that are belonged to this genus are being used in the traditional system of medicine in Asian countries, especially in China, India, and Bangladesh. The genus Syzygium comprises 1200–1800 species that belong to the family of Myrtaceae. K E Y W O R D S antidepressant, antioxidant effects, anxiolytic, Blumea lacera, gamma-sitosterol, thymol Taken these results as a base, the plant has imperative potentials in managing anxiety and depression-like disorders. beta.-ol and gamma-sitosterol possessed promising antidepressant effects. Specifically, thymol and cuminol revealed potential anxiolytic and antioxidant effects, while stigmast-5-en-3. Correspondingly, the computer-aided investigation confirmed several bioactive lead molecules. The antioxidative effects of Me-BLL have also been observed prominently.
The TST and FST revealed a decrease in immobility time, meaning the persuasive antidepressant effects. The EPM and LDB tests demonstrated an increased time spent in open arms and light box, and the HBT showed an increased number of head dipping, indicating the anxiolytic effects of Me-BLL. The phytochemical analyses revealed several bioactive metabolites, including higher contents of total phenolics and flavonoids. Diazepam (1 mg/kg, i.p.) and fluoxetine HCl (20 mg/kg, p.o.) were used as the reference standard.
The anxiolytic effects were observed employing elevated plus maze (EPM), light-dark box (LDB), and hole-board (HBT) tests, while antidepressant effects were evaluated using forced swimming (FST) and tail suspension tests (TST). To explore the neuropharmacological insights, Swiss albino mice were treated with Me-BLL at doses of 200-400 mg/kg, p.o. The chemical characterization of Me-BLL was performed through standard phytochemical and GC-MS analyses. lacera methanol leaf extract (Me-BLL) in attenuating anxiety and depression through several experimental and computer-aided approaches. Therefore, the current study aims to explore the impending bioactive metabolites and roles of B. However, the an-xiolytic and antidepressant roles of B. Blumea lacera is an edible plant with imperative medicinal values.
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